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First published online 29 July 2008
doi: 10.1242/jcs.027151

Journal of Cell Science 121, 2751-2758 (2008)
Published by The Company of Biologists 2008
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Research Article

P311 functions in an alternative pathway of lipid accumulation that is induced by retinoic acid

James K. Leung1, Sylvaine Cases2 and Thiennu H. Vu1,*

1 Lung Biology Center and Department of Medicine, University of California, San Francisco, CA 94143, USA
2 Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA

* Author for correspondence (e-mail: thiennu.vu{at}ucsf.edu)

Accepted 16 June 2008

Lipid droplets are complex and dynamic intracellular organelles that have an essential role in cholesterol and lipid homeostasis, and profoundly affect cellular structure and function. Variations in lipid-droplet composition exist between different cell types, but whether there are differences in the mechanisms of lipid-droplet accumulation remains to be elucidated. Here, we report that P311, previously identified to have a function in neuronal regeneration and a potential role in distal lung generation, regulates lipid droplet accumulation. P311 upregulates several classes of genes associated with lipid synthesis, significantly increases intracellular cholesterol and triglyceride levels, and increases intracellular lipid droplets. Interestingly, P311 expression is not necessary for lipogenesis in the well-established NIH3T3-L1 cell model of adipogenic differentiation. Instead, we demonstrate a novel role for P311 in an alternative pathway of lipid-droplet accumulation that is induced by the regeneration-inducing molecule retinoic acid.

Key words: P311 (D0H4S114, C5orf13), Lipid droplet Accumulation, Retinoic acid






© The Company of Biologists Ltd 2008