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First published online 12 August 2008
doi: 10.1242/jcs.025684

Journal of Cell Science 121, 2951-2960 (2008)
Published by The Company of Biologists 2008
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Research Article

Gain and fidelity of transmission patterns at cortical excitatory unitary synapses improve spike encoding

Jin-Hui Wang1,*, Jian Wei1, Xin Chen1, Jiandong Yu1, Na Chen1 and Jack Shi2

1 State Key Labs for Macrobiomolecules and Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, The People's Republic of China
2 Department of Physics, University of Kansas, Lawrence, KS 66049, USA

* Author for correspondence (e-mail: jhw{at}sun5.ibp.ac.cn)

Accepted 13 May 2008

Neuronal spike encoding and synaptic transmission in the brain need be precise and reliable for well-organized behavior and cognition. Little is known about how a unitary synapse reliably transmits presynaptic sequential spikes and how multiple unitary synapses precisely drive their postsynaptic neurons to encode spikes. To address these questions, we investigated the dynamics of glutamatergic unitary synapses as well as their role in driving the encoding of cortical fast-spiking neurons. Synaptic transmission patterns randomly fluctuate among facilitation, depression and parallel over time. The postsynaptic calmodulin-signaling pathway enhances initial responses and converts this fluctuation to a synaptic depression. We integrated current pulses mathematically based on synaptic plasticity and found that they improve spike capacity and timing precision by shortening the spike refractory period at postsynaptic neurons. Our results indicate that the gain and fidelity of synaptic patterns enable reliable transmission of presynaptic signals by the synapse and precise encoding of spikes by postsynaptic neurons. These reproducible neural codes may be involved in controlling well-organized behavior.

Key words: Unitary synapse, Synaptic plasticity, Interneuron, Action potential, Spike timing, Calcineurin, Ca2+-calmodulin


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N. Chen, X. Chen, and J.-H. Wang
Homeostasis established by coordination of subcellular compartment plasticity improves spike encoding
J. Cell Sci., September 1, 2008; 121(17): 2961 - 2971.
[Abstract] [Full Text] [PDF]


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