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First published online September 3, 2008
doi: 10.1242/10.1242/jcs.030643

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Centrin4 coordinates cell and nuclear division in T. brucei

Jie Shi¹, Joseph B. Franklin², Jordan T. Yelinek², Ingo Ebersberger^3,4, Graham Warren^2,* and Cynthia Y. He^2,,

¹ Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543
² Department of Cell Biology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
³ Centre for Integrative Bioinformatics Vienna, Max F. Perutz Laboratories, Dr Bohr-Gasse 9, A-1030 Vienna, Austria
⁴ University of Veterinary Medicine, Veterinärplatz 1, 1210 Vienna, Austria

Author for correspondence (e-mail: dbshyc{at}nus.edu.sg)

Accepted 2 July 2008

Centrins are Ca²⁺-binding proteins that have been implicated in a number of biological processes, including organelle duplication, mRNA export, DNA repair and signal transduction. In the protozoan parasite Trypanosoma brucei we have previously described TbCentrin2, which is present on a bi-lobed structure, and involved in the duplication and segregation of the Golgi complex. Recently, another centrin, TbCentrin4, was also found at the bi-lobe and has been implicated in organelle segregation and cytokinesis. We now show that cytokinesis is not inhibited, but that a dysregulation of nuclear and cell division leads to the production of zoids – daughter siblings that contain all organelles except the nucleus. Our results, therefore, suggest that TbCentrin4 is involved in processes that coordinate karyokinesis and cytokinesis.

Key words: Trypanosoma brucei, Centrin, Basal body, Golgi, Cell division, Zoid

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