spacer gif spacer gif spacer gif spacer gif Propose a workshop for 2011 spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

First published online March 5, 2008
doi: 10.1242/10.1242/jcs.000455

Journal of Cell Science 121, 727-735 (2008)
Published by The Company of Biologists 2008
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wheelock, M. J.
Right arrow Articles by Johnson, K. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wheelock, M. J.
Right arrow Articles by Johnson, K. R.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Commentary

Cadherin switching

Margaret J. Wheelock*, Yasushi Shintani, Masato Maeda, Yuri Fukumoto and Keith R. Johnson

University of Nebraska Medical Center, Department of Oral Biology and Eppley Cancer Center, Omaha, NE 68198-7696, USA

* Author for correspondence (e-mail: mwheelock{at}unmc.edu)

Accepted 17 December 2007

The cadherin molecules at adherens junctions have multiple isoforms. Cadherin isoform switching (cadherin switching) occurs during normal developmental processes to allow cell types to segregate from one another. Tumor cells often recapitulate this activity and the result is an aggressive tumor cell that gains the ability to leave the site of the tumor and metastasize. At present, we understand some of the mechanisms that promote cadherin switching and some of the pathways downstream of this process that influence cell behavior. Specific cadherin family members influence growth-factor-receptor signaling and Rho GTPases to promote cell motility and invasion. In addition, p120-catenin probably plays multiple roles in cadherin switching, regulating Rho GTPases and stabilizing cadherins.

Key words: Cadherin, Biology, Switching


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Cold Spring Harb. Perspect. Biol.Home page
P. D. McCrea, D. Gu, and M. S. Balda
Junctional Music that the Nucleus Hears: Cell-Cell Contact Signaling and the Modulation of Gene Activity
Cold Spring Harb Perspect Biol, October 1, 2009; 1(4): a002923 - a002923.
[Abstract] [Full Text] [PDF]

Home page
 Cold Spring Harb. Perspect. Biol.Home page
W. W. Franke
Discovering the Molecular Components of Intercellular Junctions--A Historical View
Cold Spring Harb Perspect Biol, September 1, 2009; 1(3): a003061 - a003061.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
C.-W. Chua, Y.-T. Chiu, H.-F. Yuen, K.-W. Chan, K. Man, X. Wang, M.-T. Ling, and Y.-C. Wong
Suppression of Androgen-Independent Prostate Cancer Cell Aggressiveness by FTY720: Validating Runx2 as a Potential Antimetastatic Drug Screening Platform
Clin. Cancer Res., July 1, 2009; 15(13): 4322 - 4335.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
M. E. Diamond, L. Sun, A. J. Ottaviano, M. J. Joseph, and H. G. Munshi
Differential growth factor regulation of N-cadherin expression and motility in normal and malignant oral epithelium
J. Cell Sci., July 1, 2008; 121(13): 2197 - 2207.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2008