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First published online April 23, 2008
doi: 10.1242/10.1242/jcs.026401

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The ins and outs of syntenin, a multifunctional intracellular adaptor protein

Departments of Immunology and Pediatric Immunology, Wilhelmina Children's Hospital, University Medical Center, Lundlaan 6, 3584 EA Utrecht, The Netherlands

^* Author for correspondence (e-mail: P.J.Coffer{at}umcutrecht.nl)

Accepted 13 March 2008

One of the most challenging issues currently facing cell biologists is how signal specificity and compartmentalization is achieved, allowing extracellular stimulation to result in a unique and pre-defined intracellular outcome. For this to occur, intracellular components must be correctly positioned in both space and time. Adaptor molecules, which contain protein-interaction domains, are often involved in the assembly of multimeric complexes that organize intracellular signal-transduction pathways. One such protein is syntenin, a PDZ-domain-containing molecule that has a surprising variety and diversity of interaction partners. Here we assimilate and discuss current data that support a role for syntenin in regulating transmembrane-receptor trafficking, tumour-cell metastasis and neuronal-synapse function.

Key words: Syntenin, Adaptor, PDZ domain