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First published online May 20, 2009
doi: 10.1242/10.1242/jcs.045849

Journal of Cell Science 122, 1834-1841 (2009)
Published by The Company of Biologists 2009
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Research Article

Coatomer-dependent protein delivery to lipid droplets

Krishnakant G. Soni, Gonzalo A. Mardones, Rachid Sougrat, Elena Smirnova, Catherine L. Jackson*,{dagger} and Juan S. Bonifacino{dagger}

Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA

{dagger} Authors for correspondence (e-mails: jackson{at}lebs.cnrs-gif.fr; juan{at}helix.nih.gov)

Accepted 13 February 2009

Lipid droplets (LDs) are cytoplasmic organelles that store neutral lipids for use as an energy supply in times of nutrient deprivation and for membrane assembly. Misregulation of LD function leads to many human diseases, including lipodystrophy, obesity and neutral lipid storage disorders. A number of proteins have been shown to localize to the surface of lipid droplets, including lipases such as adipose triglyceride lipase (ATGL) and the PAT-domain proteins ADRP (adipophilin) and TIP47, but the mechanism by which they are targeted to LDs is not known. Here we demonstrate that ATGL and ADRP, but not TIP47, are delivered to LDs by a pathway mediated by the COPI and COPII coatomer proteins and their corresponding regulators.

Key words: ATGL, Lipid droplet, Lipid homeostasis


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JCS 2009 122: 1104. [Full Text]  



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