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First published online June 3, 2009
doi: 10.1242/10.1242/jcs.044750

Journal of Cell Science 122, 1963-1969 (2009)
Published by The Company of Biologists 2009
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Short Report

Lipin is required for efficient breakdown of the nuclear envelope in Caenorhabditis elegans

Mátyás Gorjánácz and Iain W. Mattaj*

European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117, Heidelberg, Germany

* Author for correspondence (e-mail: mattaj{at}embl.de)

Accepted 9 March 2009

Summary

The nuclear envelope (NE) is a double lipid bilayer that separates nucleus and cytoplasm. In metazoa, NE breakdown (NEBD) occurs during prophase and NE reformation around segregated chromatids occurs at anaphase-telophase. We identified Caenorhabditis elegans Lipin homologue (called Lpin-1) as an essential factor with roles in endoplasmic reticulum (ER) organization and NEBD. RNAi-mediated downregulation of Lpin-1 had no effect on timely entry into mitosis or on the early steps of NEBD, but Lpin-1 was required for disassembly of the nuclear lamina during late NEBD. This Lpin-1 requirement appears to be separable from the effect of Lpin-1 on the peripheral ER.

Key words: Nuclear-envelope breakdown, Lipin, Lamin, Diacylglycerol


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This article has been cited by other articles:


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A. Golden, J. Liu, and O. Cohen-Fix
Inactivation of the C. elegans lipin homolog leads to ER disorganization and to defects in the breakdown and reassembly of the nuclear envelope
J. Cell Sci., June 15, 2009; 122(12): 1970 - 1978.
[Abstract] [Full Text] [PDF]


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