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First published online June 17, 2009
doi: 10.1242/10.1242/jcs.028308

Journal of Cell Science 122, 2167-2177 (2009)
Published by The Company of Biologists 2009
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Commentary

No strings attached: the ESCRT machinery in viral budding and cytokinesis

Bethan McDonald and Juan Martin-Serrano*

Department of Infectious Diseases, King's College London School of Medicine, Guy's Hospital, London, SE1 9RT, UK

* Author for correspondence (e-mail: juan.martin_serrano{at}kcl.ac.uk)

This article is part of a Minifocus on the ESCRT machinery. For further reading, please see related articles: `The ESCRT machinery at a glance' by Thomas Wollert et al. (J. Cell Sci. 122, 2163-2166) and `How do ESCRT proteins control autophagy?' by Tor Erik Rusten and Harald Stenmark (J. Cell Sci. 122, 2179-2183).

Since the initial discovery of the endosomal sorting complex required for transport (ESCRT) pathway, research in this field has exploded. ESCRT proteins are part of the endosomal trafficking system and play a crucial role in the biogenesis of multivesicular bodies by functioning in the formation of vesicles that bud away from the cytoplasm. Subsequently, a surprising role for ESCRT proteins was defined in the budding step of some enveloped retroviruses, including HIV-1. ESCRT proteins are also employed in this outward budding process, which results in the resolution of a membranous tether between the host cell and the budding virus particle. Remarkably, it has recently been described that ESCRT proteins also have a role in the topologically equivalent process of cell division. In the same way that viral particles recruit the ESCRT proteins to the site of viral budding, ESCRT proteins are also recruited to the midbody – the site of release of daughter cell from mother cell during cytokinesis. In this Commentary, we describe recent advances in the understanding of ESCRT proteins and how they act to mediate these diverse processes.

Key words: Abscission, Cytokinesis, ESCRT, HIV-1, L-domain, Retroviral assembly


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Related articles in JCS:

The ESCRT machinery at a glance
Thomas Wollert, Dong Yang, Xuefeng Ren, H. H. Lee, Y. J. Im, and James H. Hurley
JCS 2009 122: 2163-2166. [Full Text]  

How do ESCRT proteins control autophagy?
T. E. Rusten and Harald Stenmark
JCS 2009 122: 2179-2183. [Abstract] [Full Text]  



This article has been cited by other articles:


Home page
 J. Cell Sci.Home page
T. Wollert, D. Yang, X. Ren, H. H. Lee, Y. J. Im, and J. H. Hurley
The ESCRT machinery at a glance
J. Cell Sci., July 1, 2009; 122(13): 2163 - 2166.
[Full Text] [PDF]


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