QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

First published online 9 June 2009
doi: 10.1242/jcs.046177

This Article Figures Only Full Text Full Text (PDF) Supplementary Material All Versions of this Article: jcs.046177v1 122/13/2185    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Hood, F. E. Articles by Royle, S. J. PubMed PubMed Citation Articles by Hood, F. E. Articles by Royle, S. J. Social Bookmarking                         What's this?

Functional equivalence of the clathrin heavy chains CHC17 and CHC22 in endocytosis and mitosis

The Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, Crown Street, Liverpool L69 3BX, UK

^* Author for correspondence (e-mail: s.j.royle{at}liverpool.ac.uk)

Accepted 23 March 2009

Summary

Clathrin is crucial for endocytosis and plays a recently described role in mitosis. Two clathrin heavy chains (CHCs) are found in humans: the ubiquitous CHC17, and CHC22, a CHC that is enriched in skeletal muscle. Functional differences have been proposed for these clathrins despite high sequence similarity. Here, we compared each paralogue in functional assays of endocytosis and mitosis. We find that CHC17 and CHC22 are functionally equivalent. We also describe how previous work on CHC22 has involved a splice variant that is not usually expressed in cells.

Key words: Cell cycle, Clathrin, Endocytosis, Mitosis

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?