QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

First published online December 31, 2008
doi: 10.1242/10.1242/jcs.018945

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Streuli, C. H. Search for Related Content PubMed PubMed Citation Articles by Streuli, C. H. Social Bookmarking                         What's this?

Integrins and cell-fate determination

Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK

e-mail: cstreuli{at}manchester.ac.uk

All cellular processes are determined by adhesive interactions between cells and their local microenvironment. Integrins, which constitute one class of cell-adhesion receptor, are multifunctional proteins that link cells to the extracellular matrix and organise integrin adhesion complexes at the cell periphery. Integrin-based adhesions provide anchor points for assembling and organising the cytoskeleton and cell shape, and for orchestrating migration. Integrins also control the fate and function of cells by influencing their proliferation, apoptosis and differentiation. Moreover, new literature demonstrates that integrins control the cell-division axis at mitosis. This extends the influence of integrins over cell-fate decisions, as daughter cells are frequently located in new microenvironments that determine their behaviour following cell division. In this Commentary, I describe how integrins influence cell-fate determination, placing particular emphasis on their role in influencing the direction of cell division and the orientation of the mitotic spindle.

Key words: Integrin signalling, Adhesion complex, Adhesome, Growth factor receptors, Proliferation, Cell cycle, Apoptosis, Anoikis, Differentiation, Stem cells, Mitosis, Metaphase, Mitotic spindle, Cell fate, Adhesion

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				J. D. Humphries, A. Byron, M. D. Bass, S. E. Craig, J. W. Pinney, D. Knight, and M. J. Humphries Proteomic Analysis of Integrin-Associated Complexes Identifies RCC2 as a Dual Regulator of Rac1 and Arf6 Sci. Signal., September 8, 2009; 2(87): ra51 - ra51. [Abstract] [Full Text] [PDF]

				N. Akhtar, R. Marlow, E. Lambert, F. Schatzmann, E. T. Lowe, J. Cheung, E. Katz, W. Li, C. Wu, S. Dedhar, et al. Molecular dissection of integrin signalling proteins in the control of mammary epithelial development and differentiation Development, March 15, 2009; 136(6): 1019 - 1027. [Abstract] [Full Text] [PDF]