QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

First published online December 31, 2008
doi: 10.1242/10.1242/jcs.041624

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Legate, K. R. Articles by Fässler, R. Search for Related Content PubMed Articles by Legate, K. R. Articles by Fässler, R. Social Bookmarking                         What's this?

Mechanisms that regulate adaptor binding to β-integrin cytoplasmic tails

Department of Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried, Germany

^* Author for correspondence (e-mail: legate{at}biochem.mpg.de)

Cells recognize and respond to their extracellular environment through transmembrane receptors such as integrins, which physically connect the extracellular matrix to the cytoskeleton. Integrins provide the basis for the assembly of intracellular signaling platforms that link to the cytoskeleton and influence nearly every aspect of cell physiology; however, integrins possess no enzymatic or actin-binding activity of their own and thus rely on adaptor molecules, which bind to the short cytoplasmic tails of integrins, to mediate and regulate these functions. Many adaptors compete for relatively few binding sites on integrin tails, so regulatory mechanisms have evolved to reversibly control the spatial and temporal binding of specific adaptors. This Commentary discusses the adaptor proteins that bind directly to the tails of β integrins and, using talin, tensin, filamin, 14-3-3 and integrin-linked kinase (ILK) as examples, describes the ways in which their binding is regulated.

Key words: Integrins, Protein modification, Signaling, Adaptors

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				J. D. Humphries, A. Byron, M. D. Bass, S. E. Craig, J. W. Pinney, D. Knight, and M. J. Humphries Proteomic Analysis of Integrin-Associated Complexes Identifies RCC2 as a Dual Regulator of Rac1 and Arf6 Sci. Signal., September 8, 2009; 2(87): ra51 - ra51. [Abstract] [Full Text] [PDF]

				K. R. Legate, S. A. Wickstrom, and R. Fassler Genetic and cell biological analysis of integrin outside-in signaling Genes & Dev., February 15, 2009; 23(4): 397 - 418. [Abstract] [Full Text] [PDF]

				S. M. Pontier and W. J. Muller Integrins in mammary-stem-cell biology and breast-cancer progression - a role in cancer stem cells? J. Cell Sci., January 15, 2009; 122(2): 207 - 214. [Abstract] [Full Text] [PDF]

				R. Evans, I. Patzak, L. Svensson, K. De Filippo, K. Jones, A. McDowall, and N. Hogg Integrins in immunity J. Cell Sci., January 15, 2009; 122(2): 215 - 225. [Abstract] [Full Text] [PDF]