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First published online December 31, 2008
doi: 10.1242/10.1242/jcs.018564

Journal of Cell Science 122, 199-206 (2009)
Published by The Company of Biologists 2009
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Commentary

Integrins in cell migration – the actin connection

Miguel Vicente-Manzanares1,*, Colin Kiwon Choi1,2 and Alan Rick Horwitz1

1 Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
2 Department of Biomedical Engineering, University of Virginia School of Medicine, Charlottesville, VA 22908, USA

* Author for correspondence (e-mail: mvicente{at}virginia.edu)

The connection between integrins and actin is driving the field of cell migration in new directions. Integrins and actin are coupled through a physical linkage, which provides traction for migration. Recent studies show the importance of this linkage in regulating adhesion organization and development. Actin polymerization orchestrates adhesion assembly near the leading edge of a migrating cell, and the dynamic cross-linking of actin filaments promotes adhesion maturation. Breaking the linkage between actin and integrins leads to adhesion disassembly. Recent quantitative studies have revealed points of slippage in the linkage between actin and integrins, showing that it is not always efficient. Regulation of the assembly and organization of adhesions and their linkage to actin relies on signaling pathways that converge on components that control actin polymerization and organization.

Key words: Actin, Integrin, Migration, Adhesion


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Related articles in JCS:

Integrin Special Issue
Arnoud Sonnenberg and Fiona M. Watt
JCS 2009 122: 157. [Full Text]  





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