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First published online December 31, 2008
doi: 10.1242/10.1242/jcs.040394

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Integrins in mammary-stem-cell biology and breast-cancer progression – a role in cancer stem cells?

Goodman Cancer Centre, McGill University, 1160 Avenue Des Pins Ouest, Montreal, Quebec, Canada H3A 1A3

^* Author for correspondence (e-mail: william.muller{at}mcgill.ca)

Cancer cells with stem cell-like properties (cancer stem cells) are believed to drive cancer and are associated with poor prognosis. Data from mouse models have demonstrated that integrins, the major cellular receptors for extracellular-matrix components, have essential roles both during cancer initiation and progression, and during cell differentiation in normal development. By presenting an overview of the role of integrins in stem-cell biology and in cancer progression, this Commentary aims to present evidence for a role of integrins in the biology of cancer stem cells. Given the recent interest in the role of integrins in breast-cancer initiation and progression, we focus on the role of the members of the integrin family and their coupled signaling pathways in mammary-gland development and tumorigenesis.

Key words: Breast cancer, Cancer stem cells, Integrin, Stem cells

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