spacer gif spacer gif spacer gif spacer gif Propose a workshop for 2011 spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

First published online December 31, 2008
doi: 10.1242/10.1242/jcs.035246

Journal of Cell Science 122, 227-232 (2009)
Published by The Company of Biologists 2009
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplementary Material
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in JCS
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Aluwihare, P.
Right arrow Articles by Munger, J. S.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Aluwihare, P.
Right arrow Articles by Munger, J. S.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Short Report

Mice that lack activity of {alpha}vβ6- and {alpha}vβ8-integrins reproduce the abnormalities of Tgfb1- and Tgfb3-null mice

Poshala Aluwihare1, Zhenyu Mu1, Zhicheng Zhao1, Dawen Yu1, Paul H. Weinreb2, Gerald S. Horan2, Shelia M. Violette2 and John S. Munger1,*

1 Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
2 Biogen Idec, Cambridge, MA 02142, USA

* Author for correspondence (e-mail: john.munger{at}nyumc.org)

Accepted 14 September 2008

Summary

The arginine-glycine-aspartate (RGD)-binding integrins {alpha}vβ6 and {alpha}vβ8 activate latent TGFβ1 and TGFβ3 in vivo, but it is uncertain whether other RGD-binding integrins such as integrins {alpha}vβ5 and {alpha}vβ3 activate these TGFβ isoforms. To define the combined role of {alpha}vβ6- and {alpha}vβ8-integrin in TGFβ activation, we analyzed mice lacking function of both integrins by means of gene deletion and/or pharmacologic inhibition. Most Itgb6–/–;Itgb8–/– embryos die at mid-gestation; those that survive develop cleft palate–as observed in Tgfb3–/– mice. Itgb8–/– mice treated with an anti-{alpha}vβ6-integrin antibody develop severe autoimmunity and lack Langerhans cells–similar to Tgfb1-null mice. These results support a model in which TGFβ3-mediated palate fusion and TGFβ1-mediated suppression of autoimmunity and generation of Langerhans cells require integrins {alpha}vβ6 and {alpha}vβ8 but not other RGD-binding integrins as TGFβ activators.

Key words: Autoimmunity, Integrins, Langerhans cells, Palate fusion, TGFb


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?

Related articles in JCS:

Keeping (TGFβ) active with integrins

JCS 2009 122: 202. [Full Text]  



This article has been cited by other articles:


Home page
 Am. J. Pathol.Home page
S. L. Nishimura
Integrin-Mediated Transforming Growth Factor-{beta} Activation, a Potential Therapeutic Target in Fibrogenic Disorders
Am. J. Pathol., October 1, 2009; 175(4): 1362 - 1370.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
A. K. Mobley, J. H. Tchaicha, J. Shin, M. G. Hossain, and J. H. McCarty
{beta}8 integrin regulates neurogenesis and neurovascular homeostasis in the adult brain
J. Cell Sci., June 1, 2009; 122(11): 1842 - 1851.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2009