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First published online 24 February 2009
doi: 10.1242/jcs.035097

Journal of Cell Science 122, 769-774 (2009)
Published by The Company of Biologists 2009
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Short Report

A product of the bicistronic Drosophila melanogaster gene CG31241, which also encodes a trimethylguanosine synthase, plays a role in telomere protection

Orban Komonyi1, Tamas Schauer1, Gabor Papai2, Peter Deak2 and Imre M. Boros1,2,*

1 Chromatin Research Group of HAS, Department of Biochemistry and Molecular Biology, University of Szeged, Közép fasor 52, H-6726 Szeged, Hungary
2 Institute of Biochemistry, Biological Research Center, Temesvari krt.62, H-6726 Szeged, Hungary

* Author for correspondence (e-mail: borosi{at}bio.u-szeged.hu)

Accepted 17 November 2008

Summary

Although telomere formation occurs through a different mechanism in Drosophila compared with other organisms, telomere associations result from mutations in homologous genes, indicating the involvement of similar pathways in chromosome end protection. We report here that mutations of the Drosophila melanogaster gene CG31241 lead to high frequency chromosome end fusions. CG31241 is a bicistronic gene that encodes trimethylguanosine synthase (TGS1), which forms the m3G caps of noncoding small RNAs, and a novel protein, DTL. We show that although TGS1 has no role in telomere protection, DTL is localized at specific sites, including the ends of polytene chromosomes, and its loss results in telomere associations. Mutations of ATM- and Rad3-related (ATR) kinase suppress telomere fusions in the absence of DTL. Thus, genetic interactions place DTL in an ATR-related pathway in telomere protection. In contrast to ATR kinase, mutations of ATM (ataxia telangiectasia mutated) kinase, which acts in a partially overlapping pathway of telomere protection, do not suppress formation of telomere associations in the absence of DTL. Thus, uncovering the role of DTL will help to dissect the evolutionary conserved pathway(s) controlling ATM-ATR-related telomere protection.

Key words: Ataxia telangiectasia mutated, ATR, Telomere, Drosophila, Bicistronic gene


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