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First published online April 1, 2009
doi: 10.1242/10.1242/jcs.039446

Journal of Cell Science 122, 1059-1069 (2009)
Published by The Company of Biologists 2009
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Commentary

Adhesion signaling – crosstalk between integrins, Src and Rho

Stephan Huveneers* and Erik H. J. Danen

Division of Toxicology, Leiden Amsterdam Center for Drug Research, Leiden University, Einsteinweg 55, 2300 RA Leiden, The Netherlands

e-mails: e.danen{at}lacdr.leidenuniv.nl; s.huveneers{at}niob.knaw.nl

Interactions between cells and the extracellular matrix coordinate signaling pathways that control various aspects of cellular behavior. Integrins sense the physical properties of the extracellular matrix and organize the cytoskeleton accordingly. In turn, this modulates signaling pathways that are triggered by various other transmembrane receptors and augments the cellular response to growth factors. Over the past years, it has become clear that there is extensive crosstalk between integrins, Src-family kinases and Rho-family GTPases at the heart of such adhesion signaling. In this Commentary, we discuss recent advances in our understanding of the dynamic regulation of the molecular connections between these three protein families. We also discuss how this signaling network can regulate a range of cellular processes that are important for normal tissue function and disease, including cell adhesion, spreading, migration and mechanotransduction.

Key words: Adhesion, Spreading, Engulfment, Migration, Invasion, Integrins, Rho-GTPases, Src-family kinases, Extracellular matrix, Mechanotransduction


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This article has been cited by other articles:


Home page
 Sci SignalHome page
E. H. J. Danen
Integrin Proteomes Reveal a New Guide for Cell Motility
Sci. Signal., September 22, 2009; 2(89): pe58 - pe58.
[Abstract] [Full Text] [PDF]


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