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First published online April 22, 2009
doi: 10.1242/10.1242/jcs.039990

Journal of Cell Science 122, 1275-1284 (2009)
Published by The Company of Biologists 2009
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Commentary

CTCF and its protein partners: divide and rule?

Jordanka Zlatanova1,* and Paola Caiafa2

1 Department of Molecular Biology, University of Wyoming, Laramie, WY 82071, USA
2 Department of Cellular Biotechnology and Hematology, Second Faculty of Medicine and Surgery, University `La Sapienza', and Pasteur Institute-Fondazione Cenci Bolognetti, 00161 Rome, Italy

* Author for correspondence (e-mail: jordanka{at}uwyo.edu)

CTCF is a ubiquitous transcription factor that is involved in numerous, seemingly unrelated functions. These functions include, but are not limited to, positive or negative regulation of transcription, enhancer-blocking activities at developmentally regulated gene clusters and at imprinted loci, and X-chromosome inactivation. Here, we review recent data acquired with state-of-the-art technologies that illuminate possible mechanisms behind the diversity of CTCF functions. CTCF interacts with numerous protein partners, including cohesin, nucleophosmin, PARP1, Yy1 and RNA polymerase II. We propose that CTCF interacts with one or two different partners according to the biological context, applying the Roman principle of governance, `divide and rule' (divide et impera).

Key words: Cohesin, Nucleophosmin, PARP1, RNA polymerase II, Yy1


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This article has been cited by other articles:


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 J Mol Cell BiolHome page
L. A. Diaz-Martinez and H. Yu
Cohesin: A Multi-purpose Chromatin Glue
J Mol Cell Biol, August 14, 2009; (2009) mjp014v1.
[Abstract] [Full Text] [PDF]


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