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First published online February 9, 2010
doi: 10.1242/10.1242/jcs.066308

Journal of Cell Science 123, 505-509 (2010)
Published by The Company of Biologists 2010
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Opinion

Sensory reception is an attribute of both primary cilia and motile cilia

Robert A. Bloodgood

Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22908-0732, USA

rab4m{at}virginia.edu

A recent cluster of papers has shown that motile cilia in the respiratory and reproductive tracts of humans and other mammals can exhibit sensory functions, a function previously attributed primarily to non-motile primary cilia. This leads to a new paradigm that all cilia and flagella (both motile and primary) can mediate sensory functions. However, examination of the literature shows that evidence of sensory functions of motile cilia and flagella is widespread in studies of invertebrates, and extends as back as far as 1899. In this Opinion article, I review the recent and historical findings that motile cilia have a variety of sensory functions, and discuss how this concept has in fact been evolving for the past century.

Key words: Cilia, Flagella, Motile, Sensory, Signaling


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Related articles in JCS:

The primary cilium at a glance
Peter Satir, Lotte B. Pedersen, and Søren T. Christensen
JCS 2010 123: 499-503. [Full Text]  

The perennial organelle: assembly and disassembly of the primary cilium
E. Scott Seeley and Maxence V. Nachury
JCS 2010 123: 511-518. [Abstract] [Full Text]  

Flagellar and ciliary beating: the proven and the possible
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JCS 2010 123: 519-528. [Abstract] [Full Text]  

Molecular mechanisms of protein and lipid targeting to ciliary membranes
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MINIFOCUS: Cilia and flagella

JCS 2010 123: 401. [Full Text]  





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