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Journal of Cell Science, Vol 13, 901-911, Copyright © 1973 by Company of Biologists

Submitted on March 8, 1973

Ruthenium-Red-Induced Cell Agglutination and Surface Glycoprotein and Muco-Polysaccharide

KOZO UTSUMI 1 and TAKUZO ODA 1

1 Department of Biochemistry, Cancer Institute, Okayama University Medical School, Okayama 700, Japan

Ruthenium red induces the agglutination of ascites hepatoma cells. The agglutination was inhibited by acidic polysaccharides but not by haptenic inhibitors of some plant agglutinins. The agglutination was also abolished by treatment of the cells with a low concentration of papain. Papain digestion causes a decrease in the number of microvilli on the cell surface and the release of carbohydrate-containing red-binding substance. One of them is a heparan sulphate-like mucopolysaccharide and the other is a glycoprotein which contains sialic acid. The ruthenium red-binding fractions inhibit the cell agglutination induced by ruthenium red.

Submitted on March 8, 1973






© The Company of Biologists Ltd 1973