spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by BOURNE, R. A.
Right arrow Articles by FALCORNER, I. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by BOURNE, R. A.
Right arrow Articles by FALCORNER, I. R.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Journal of Cell Science, Vol 14, 105-111, Copyright © 1974 by Company of Biologists

Submitted on May 24, 1973

Stimulation of DNA Synthesis by Prolactin in Rabbit Mammary Tissue

R. A. BOURNE 1, J. A. BRYANT 2, and I. R. FALCORNER 3

1 Department of Applied Biochemistry and Nutrition, Nottingham University School of Agriculture Sutton Bonington, Loughborough, LEI2 5RD, England; Department of Dairy Science, Michigan State University, East Lansing, Michigan, 48823, U.S.A.
2 Department of Applied Biochemistry and Nutrition, Nottingham University School of Agriculture Sutton Bonington, Loughborough, LEI2 5RD, England
3 Department of Applied Biochemistry and Nutrition, Nottingham University School of Agriculture Sutton Bonington, Loughborough, LEI2 5RD, England; Department of Biochemistry and Nutrition, University of New England, Armidale, New South Wales, Australia.

The capacity of mammary gland tissue slices to incorporate [3H]thymidine into DNA was studied at intervals after intraductal injection of prolactin. Prolactin markedly increased the rate of incorporation of thymidine into DNA (as extracted by HCIO4 or by sodium dodecyl sulphate). The increase in incorporation rate occurred within 6 h of prolactin injection. Autoradiography of mammary tissue, after administration of [8H]thymidine in vivo, showed that the increased rate of incorporation of thymidine was caused by an increase in the number of alveolar cells entering S-phase. These results are discussed in relation to current theories concerning functional differentiation of mammary tissue.

Submitted on May 24, 1973


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?




© The Company of Biologists Ltd 1974