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Journal of Cell Science, Vol 16, 181-188, Copyright © 1974 by Company of Biologists

Submitted on February 19, 1974

Release from Density-Dependent Inhibition of Growth in the Absence of Cell Locomotion

MARGARET M. YARNELL 1 and H. P. SCHNEBLI 2

1 Friedrich Miescher-Institut, Basel, Switzerland; Abteilung für Krebsforschung, Institut für Pathologische Anatomie, Aussenstation Universität Zürich, Birchstrasse 95, CH-8050 Zürich, Switzerland
2 Friedrich Miescher-Institut, Basel, Switzerland

3T3 mouse fibroblasts are released from density-dependent inhibition of growth by treatment with insulin. The same insulin treatment stimulates cell locomotion several hours before any new mitoses become visible. Inhibition of cell locomotion by colcemid does not affect the overgrowth stimulation due to insulin. From this it is concluded that cellular locomotion is not a prerequisite for the release from density-dependent inhibition of growth.

Submitted on February 19, 1974






© The Company of Biologists Ltd 1974