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Journal of Cell Science, Vol 19, Issue 2 281-303, Copyright © 1975 by Company of Biologists

JOURNAL ARTICLES

Perturbation of mammalian cell division. II. Studies on the isolation and characterization of human mini segregant cells

SL Schor, RT Johnson and AM Mullinger

A method is described for the isolation, according to size, of mini segregants produced by the abnormal cleavage of reversibly arrested mitotic HeLa cells. Many of these mini segregants contain small amounts of DNA, as judged by Feulgen staining and chromosome analysis. After fusion with mitotic HeLa cells, the interphase chromosomes of the mini segregants are seen as either monovalent or bivalent prematurely condensed chromosomes (PCC), some of which are damaged. A proportion of isolated mini segregants synthesize DNA, RNA and protein. Fusion of mini segregants with interphase HeLa cells gives rise to cells with 'hybrid' karyotypes.


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V. McKusick and F. Ruddle
The status of the gene map of the human chromosomes
Science, April 22, 1977; 196(4288): 390 - 405.
[Abstract] [PDF]


© The Company of Biologists Ltd 1975