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Journal of Cell Science, Vol 22, Issue 1 49-58, Copyright © 1976 by Company of Biologists

JOURNAL ARTICLES

A theoretical study of the effects of cyclic AMP phosphodiesterases during aggregation in Dictyostelium

V Nanjundiah and D Malchow

During aggregation the larger Dictyostelium species use cAMP as a chemoattractant and possibly also as a transmitter. In passage from cell to cell, cAMP levels are modulated by diffusion and by enzyme hydrolysis. It appears that the important cAMP-hydrolysing enzyme is a phosphodiesterase bound to the cell membrane, the main roles of which are (1) very fast hydrolysis of cAMP and (2) steepening of spatial cAMP gradients. An extracellular phosphodiesterase has no function, so far as can be conjectured from present data.
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© The Company of Biologists Ltd 1976