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Journal of Cell Science, Vol 22, Issue 3 671-684, Copyright © 1976 by Company of Biologists

JOURNAL ARTICLES

Mechanisms of cell adhesion: early-forming junctions between aggregating fibroblasts

CW Lloyd, DA Rees, CG Smith and FJ Judge

When cultured fibroblasts (16C) are mildly dissociated with EGTA or trypsin/EDTA, they aggregate rapidly. The formation of aggregates has been found to involve junctions of the gap and adhaerens types which are seen by electron microscopy within minutes of allowing cells to come together. The process of adhesion between freshly dissociated, transformed 16C fibroblasts is therefore organized and establishes its usefulness as a model for studying cellular interactions in relation to supracellular organization.




© The Company of Biologists Ltd 1976