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Journal of Cell Science, Vol 28, Issue 1 107-116, Copyright © 1977 by Company of Biologists

JOURNAL ARTICLES

An inhibitor of cell cohesion from axenically grown cells of the slime mould, Dictyostelium discoideum

AP Swan, DR Garrod and D Morris

Medium from a stationary phase culture of axenically grown D. discoideum cells contains an inhibitor of cohesion of log phase cells. The inhibitor is a heat-stable, low molecular weight substance. Its biological effects include inhibition of cohesion of aggregation-competent cells, of cells of other slime mould species, the blocking of development on Millipore filters and a reduction in adhesiveness of slime mould cells to glass. Present evidence suggests that the inhibitor may bind to the cell surface.




© The Company of Biologists Ltd 1977