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Journal of Cell Science, Vol 29, Issue 1 249-269, Copyright © 1978 by Company of Biologists

JOURNAL ARTICLES

The cellular origin of chemically induced tumours

PM Iannaccone, RL Gardner and H Harris

Tumours were induced by chemical carcinogens in chimaeric mice made by the amalgamation of two embryos each producing a different electrophoretic variant of the enzyme glucose phosphate isomerase. Although, in these chimaeras, the smallest samples of normal tissue that could be analysed almost invariably contained both isoenzymes, almost all the tumours contained only one. An analysis of the size of the clones that formed the chimaeric epidermis permitted the conclusion that the epidermal tumours produced could not have risen from more than 8 cells; and the most probable interpretation of the data is that these tumours were clonal growths.


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I. Fidler and I. Hart
Biological diversity in metastatic neoplasms: origins and implications
Science, September 10, 1982; 217(4564): 998 - 1003.
[Abstract] [PDF]


© The Company of Biologists Ltd 1978