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Journal of Cell Science, Vol 3, 245-262, Copyright © 1968 by Company of Biologists

Submitted on September 2, 1967

Cytological and Cytochemical Studies on Cell Death and Digestion in the Foetal Rat Foot

The Role of Macrophages and Hydrolytic Enzymes

KATHLEEN J. BALLARD 1 and S. J. HOLT 1

1 Department of Cytochemistry, Courtauld Institute of Biochemistry, Middlesex Hospital Medical School London, W. 1

Physiological cell death and degeneration in the interdigital mesenchyme of the hind foot of the rat foetus have been studied using classical staining methods and staining methods for enzyme localization. Individual mesenchymal cells die and shrink as the result of some unknown mechanism. Their acid phosphatase and esterase activities are not significantly different from those of viable loose mesenchymal cells. The dead cells are engulfed by viable neighbouring cells which resemble other loose mesenchymal cells in their morphology and in their acid phosphatase and esterase activities. These phagocytes then differentiate and become typical macrophages. Expressions of this process are the altered appearance of their nuclei and the increase in cytoplasm and in acid phosphatase and esterase activities. Many dead cells may be engulfed by a single macrophage and are then digested by its acid hydrolases. No evidence was found suggesting that cell death might be initiated by the intracellular release of lysosomal enzymes.

Submitted on September 2, 1967




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© The Company of Biologists Ltd 1968