spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Schor, S. L.
Right arrow Articles by Court, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schor, S. L.
Right arrow Articles by Court, J.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Journal of Cell Science, Vol 38, Issue 1 267-281, Copyright © 1979 by Company of Biologists

JOURNAL ARTICLES

Different mechanisms in the attachment of cells to native and denatured collagen

SL Schor and J Court

The attachment of cells to collagen has been reported previously to require the presence of serum and the particular serum protein involved in this process, variously known as CIG, CAP or fibronectin, has been isolated. This conclusion that cell attachment to collagen requires serum (or more precisely, fibronectin) is based on experiments measuring the kinetics of cell attachment to films of collagen. We have measured the kinetics of attachment of HeLa and attachment to films of collagen-containing substrata under a variety of experimental conditions and present evidence that the serum-dependent mechanism of cell attachment described by others is actually only the case for films of denatured collagen, while cell attachment to native collagen fibres occurs by a different, serum-independent, mechanism. The possible relevance of these findings to cell-matrix interactions in vivo is discussed.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 DevelopmentHome page
I Ellis, J Banyard, and S. Schor
Differential response of fetal and adult fibroblasts to cytokines: cell migration and hyaluronan synthesis
Development, January 4, 1997; 124(8): 1593 - 1600.
[Abstract] [PDF]

Home page
 J. Cell Sci.Home page
S. Schor, I Ellis, C Dolman, J Banyard, M. Humphries, D. Mosher, A. Grey, A. Mould, J Sottile, and A. Schor
Substratum-dependent stimulation of fibroblast migration by the gelatin-binding domain of fibronectin
J. Cell Sci., January 10, 1996; 109(10): 2581 - 2590.
[Abstract] [PDF]

Home page
 J. Cell Sci.Home page
D. Tuckwell, S Ayad, M. Grant, M Takigawa, and M. Humphries
Conformation dependence of integrin-type II collagen binding. Inability of collagen peptides to support alpha 2 beta 1 binding, and mediation of adhesion to denatured collagen by a novel alpha 5 beta 1-fibronectin bridge
J. Cell Sci., January 4, 1994; 107(4): 993 - 1005.
[Abstract] [PDF]

Home page
 J Biomater ApplHome page
C. J. Doillon
Porous Collagen Sponge Wound Dressings: in vivo and in vitro Studies
J Biomater Appl, January 1, 1987; 2(4): 562 - 578.
[Abstract] [PDF]

Home page
 ScienceHome page
R. Day and H. Lenhoff
Hydra mesoglea: a model for investigating epithelial cell--basement membrane interactions
Science, January 16, 1981; 211(4479): 291 - 294.
[Abstract] [PDF]


© The Company of Biologists Ltd 1979