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Journal of Cell Science, Vol 45, Issue 1 31-39, Copyright © 1980 by Company of Biologists

JOURNAL ARTICLES

On the role of small peptides in the regulation of RNA synthesis in Tetrahymena pyriformis

HA Andersen, AE Lykkesfeldt and SJ Nielsen

Tetrahymena cells secrete a factor which inhibits RNA synthesis in vivo and in vitro. The factor is a relatively small peptide with a molecular weight between 300 and 1500 Daltons. Other, non-specific peptides in the broth medium or added to a chemically defined medium have a stimulatory effect on RNA synthesis in vivo and such peptides also stimulate the in vitro synthesis of RNA in a r-chromatin preparation. On the basis of these results we conclude that such extracellular small peptides compete with a specific factor which is part of the intracellular regulatory mechanism controlling the rate of RNA synthesis. The consequence of such competition is a high overproduction of ribosomal RNA in cells inoculated on peptide-rich broth media.




© The Company of Biologists Ltd 1980