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Journal of Cell Science, Vol 49, Issue 1 299-310, Copyright © 1981 by Company of Biologists

JOURNAL ARTICLES

The effects of fibronectin on the adhesion and migration of chinese hamster ovary cells on collagen substrata

SL Schor, AM Schor and GW Bazill

Data are presented indicating that the adhesion of Chinese hamster ovary cells (CHO) to films of denatured type I collagen occurs by a fibronectin-dependent mechanism, whereas the adhesion of these cells to 3-dimensional gels of native type I collagen fibres may occur by either a rapid, fibronectin-dependent mechanism or by a slower, fibronectin-independent mechanism, whereas the adhesion of these cells to 3-dimensional gels of native type I collagen fibres may occur by either a rapid, fibronectin-dependent mechanism or by a slower, fibronectin-independent mechanism. Data are also presented indicating that fibronectin promotes the migration of CHO cells on native type I collagen fibres.


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S. Schor, I Ellis, C Dolman, J Banyard, M. Humphries, D. Mosher, A. Grey, A. Mould, J Sottile, and A. Schor
Substratum-dependent stimulation of fibroblast migration by the gelatin-binding domain of fibronectin
J. Cell Sci., January 10, 1996; 109(10): 2581 - 2590.
[Abstract] [PDF]


© The Company of Biologists Ltd 1981