spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Geurts van Kessel, A. H.
Right arrow Articles by Hagemeijer, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Geurts van Kessel, A. H.
Right arrow Articles by Hagemeijer, A.

Journal of Cell Science, Vol 51, Issue 1 121-130, Copyright © 1981 by Company of Biologists

JOURNAL ARTICLES

Expression of chronic myeloid leukaemia-associated changes in membrane glycopeptides in somatic cell hybrids

AH Geurts van Kessel, LA Smets, H van Rooy and A Hagemeijer

Hybrid cell lines, derived from fusion of rodent cells with peripheral leukocytes from patients with chronic myeloid leukaemia (CML) and from normal donors, were assayed for the present of CML-associated changes in the carbohydrate moieties of membrane glycoproteins. Expression of this characteristic phenotype did occur in several hybrid clones derived from fusions both with leukaemic and normal human leukocytes. But, expression was only observed when tumourigenic rodent cells were used as fusion partners, and was not observed after fusion with non-tumourigenic rodent cells. Chromosome analysis of the hybrid cells did not reveal a single human chromosome- or chromosomal aberration (e.g. the Philadelphia chromosome)-bearing factor(s) responsible for this expression. The phenotypic expression observed could be due to dissociation of certain human genes from their regulator(s), as a result of chromosome loss in interspecific cell hybrids.




© The Company of Biologists Ltd 1981