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Journal of Cell Science, Vol 55, Issue 1 69-83, Copyright © 1982 by Company of Biologists

JOURNAL ARTICLES

Enzymic dissection of embryonic cell adhesive mechanisms. III. Immunological identification of a component of the calcium-dependent adhesive system of embryonic chick neural retina cells

GB Grunwald, RS Pratt and J Lilien

Immunological probes and cell-surface biochemical analysis are combined to identify a cell-surface glycoprotein, which appears to be involved in the formation of calcium-dependent adhesions among embryonic chick neural retina cells. Comparison of radioiodinated cells shows that adhesive-competent cells have at their surface two glycoproteins not present on non-adhesive cells. These two components (with Mr 130 x 10(3), pI 4.8 and Mr 70 x 10(3), pI 4.8) are immunoprecipitable with adhesion-blocking antisera. A fraction derived from retina-conditioned medium, containing one major immunoprecipitable component, neutralizes the inhibitory activity of aggregation-inhibiting Fab' fragments and competes in immunoprecipitation for the two glycoprotein components. The evidence suggests that one or both of these components is involved in the formation of calcium-dependent adhesions among embryonic chick neural retina cells.


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G. Edelman
Cell adhesion molecules
Science, February 4, 1983; 219(4584): 450 - 457.
[Abstract] [PDF]


© The Company of Biologists Ltd 1982