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Journal of Cell Science, Vol 6, 721-737, Copyright © 1970 by Company of Biologists

Submitted on July 29, 1969

The Effects of Some Metabolic Inhibitors on the Ability of SV 40 Virus in Transformed Cells to be Detected by Cell Fusion

J. F. WATKINS 1

1 Sir William Dunn School of Pathology, Oxford, England

When mouse fibroblasts transformed by SV 40 virus are fused with African Green Monkey kidney cells about 5% of the heterokaryons produce infective SV 40 virus. If the transformed mouse cells are treated with iododeoxyuridine before fusion, the percentage of heterokaryons producing SV 40 virus is increased to between 50 and 80%; if the transformed cells are treated with 8-azaguanine, the percentage of heterokaryons yielding virus is increased to between 59% and 96%. This shows that whether the SV 40 virus can be detected by cell fusion depends on the state of the transformed cells beforehand. A new method for titrating SV 40 virus is described.

Submitted on July 29, 1969




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J. Green and S Baron
5-iododeoxyuridine potentiation of the replication in vitro of several unrelated RNA and DNA viruses
Science, December 12, 1975; 190(4219): 1099 - 1101.
[Abstract] [PDF]


© The Company of Biologists Ltd 1970