spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Higson, F. K.
Right arrow Articles by Hughes, G. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Higson, F. K.
Right arrow Articles by Hughes, G. M.

Journal of Cell Science, Vol 64, Issue 1 323-330, Copyright © 1983 by Company of Biologists

JOURNAL ARTICLES

Effects of respiratory-burst stimuli on the flow properties of pig blood neutrophils

FK Higson, Y Kikuchi, OT Jones and GM Hughes

Stimulants of the neutrophil respiratory burst, both soluble and crystalline, greatly inhibit the flow of cells through a Nuclepore filter with 5 micron diameter pores. The stimuli appear to reduce cell deformability by a mechanism independent of the activation of respiration, since inhibitors of the respiratory burst (N-phenyl maleimide, quercetin) are without effect on the change. It is suggested that stimuli reduce membrane deformability rather than cause aggregation, since slowing of flow is independent of cell density and is much less when the filter pore size is increased to 8 micron. The technique, recently used to study alterations in erythrocyte deformability, may be appropriate for investigating leucocyte flow in some clinical disorders.


This article has been cited by other articles:


Home page
 J. Leukoc. Biol.Home page
H. Saito, Y. Minamiya, U. Kalina, S. Saito, and J.-i. Ogawa
Effect of antithrombin III on neutrophil deformability
J. Leukoc. Biol., September 1, 2005; 78(3): 777 - 784.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 1983