|
|
|
|
|
|
|
|
|||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | |||||
Journal of Cell Science, Vol 73, Issue 1 105-119, Copyright © 1985 by Company of Biologists
JOURNAL ARTICLES |
RM Hembry, G Murphy and JJ Reynolds
A specific antiserum to pure human amniotic fluid metalloproteinase inhibitor (TIMP) was raised in a sheep. This antiserum was used to demonstrate: firstly, the immunological identity of the TIMP activities from amniotic fluid and culture medium of human foetal lung fibroblasts; and secondly, by indirect immunofluorescence, the secretion of TIMP by human foetal lung fibroblasts, chondrocytes, epithelial cells and smooth muscle cells. The phorbol ester, 12-O-tetradecanoylphorbol-13-acetate, was used to stimulate secretion of TIMP by human foetal lung fibroblasts and the ionophore monensin was used to demonstrate intracellular accumulation of TIMP in the Golgi apparatus of these cells. These results are discussed in relation to other inhibitors of collagenase reported in the literature, which are probably identical to TIMP.
This article has been cited by other articles:
|
|
 |
|
  S. O. Wurtz, I. J. Christensen, A.-S. Schrohl, H. Mouridsen, U. Lademann, V. Jensen, and N. Brunner Measurement of the Uncomplexed Fraction of Tissue Inhibitor of Metalloproteinases-1 in the Prognostic Evaluation of Primary Breast Cancer Patients Mol. Cell. Proteomics, April 1, 2005; 4(4): 483 - 491. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A.-S. Schrohl, M. N. Holten-Andersen, H. A. Peters, M. P. Look, M. E. Meijer-van Gelder, J. G. M. Klijn, N. Brunner, and J. A. Foekens Tumor Tissue Levels of Tissue Inhibitor of Metalloproteinase-1 as a Prognostic Marker in Primary Breast Cancer Clin. Cancer Res., April 1, 2004; 10(7): 2289 - 2298. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.-S. Schrohl, I. J. Christensen, A. N. Pedersen, V. Jensen, H. Mouridsen, G. Murphy, J. A. Foekens, N. Brunner, and M. N. Holten-Andersen Tumor Tissue Concentrations of the Proteinase Inhibitors Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) and Plasminogen Activator Inhibitor Type 1 (PAI-1) Are Complementary in Determining Prognosis in Primary Breast Cancer Mol. Cell. Proteomics, March 1, 2003; 2(3): 164 - 172. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. N. Holten-Andersen, I. J. Christensen, H. J. Nielsen, R. W. Stephens, V. Jensen, O. H. Nielsen, S. Sorensen, J. Overgaard, H. Lilja, A. Harris, et al. Total Levels of Tissue Inhibitor of Metalloproteinases 1 in Plasma Yield High Diagnostic Sensitivity and Specificity in Patients with Colon Cancer Clin. Cancer Res., January 1, 2002; 8(1): 156 - 164. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. M. Hembry, J. Dyce, I. Driesang, E. B. Hunziker, A. J. Fosang, J. A. Tyler, and G. Murphy Immunolocalization of Matrix Metalloproteinases in Partial-Thickness Defects in Pig Articular Cartilage : A Preliminary Report J. Bone Joint Surg. Am., June 1, 2001; 83(6): 826 - 838. [Abstract] [Full Text]
|
|
|
|
|
|
M. N. Holten-Andersen, R. W. Stephens, H. J. Nielsen, G. Murphy, I. J. Christensen, W. Stetler-Stevenson, and N. Brunner High Preoperative Plasma Tissue Inhibitor of Metalloproteinase-1 Levels Are Associated with Short Survival of Patients with Colorectal Cancer Clin. Cancer Res., November 1, 2000; 6(11): 4292 - 4299. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. B. Zaltsman, S. J. George, and A. C. Newby Increased Secretion of Tissue Inhibitors of Metalloproteinases 1 and 2 From the Aortas of Cholesterol Fed Rabbits Partially Counterbalances Increased Metalloproteinase Activity Arterioscler. Thromb. Vasc. Biol., July 1, 1999; 19(7): 1700 - 1707. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kranzhofer, A. H. Baker, S. J. George, and A. C. Newby Expression of Tissue Inhibitor of Metalloproteinase-1, -2, and -3 During Neointima Formation in Organ Cultures of Human Saphenous Vein Arterioscler. Thromb. Vasc. Biol., February 1, 1999; 19(2): 255 - 265. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Hill, G Murphy, A. Docherty, R. Hembry, T. Millican, J. Reynolds, and M. Meikle The effects of selective inhibitors of matrix metalloproteinases (MMPs) on bone resorption and the identification of MMPs and TIMP-1 in isolated osteoclasts J. Cell Sci., January 11, 1994; 107(11): 3055 - 3064. [Abstract] [PDF]
|
|
|
|
|
|
M. C. Meikle, S. Bord, R. M. Hembry, J. Compston, P. I. Croucher, and J. J. Reynolds Human osteoblasts in culture synthesize collagenase and other matrix metalloproteinases in response to osteotropic hormones and cytokines J. Cell Sci., December 1, 1992; 103(4): 1093 - 1099. [Abstract] [PDF]
|
|
|
|
 |
|
 E. J. Olson, J. D. Kang, F. H. Fu, H. I. Georgescu, G. C. Mason, and C. H. Evans The biochemical and histological effects of artificial ligament wear particles: In vitro and in vivo studies Am. J. Sports Med., December 1, 1988; 16(6): 558 - 570. [Abstract] [PDF]
|
|
