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Journal of Cell Science, Vol 87, Issue 3 375-381, Copyright © 1987 by Company of Biologists

JOURNAL ARTICLES

Regulation of epitectin production in a malignant cell line

SA Bader and H Harris
Sir William Dunn School of Pathology, University of Oxford, England.

RT112 cells, a line derived from a human bladder carcinoma, produce epitectin at very low levels in standard culture media; but production and secretion of this mucin are greatly increased when the cells are exposed to hyperosmotic conditions. It appears that hyperosmolarity, by inducing an increase in intracellular sodium, entrains an increase in intracellular free calcium. Evidence is presented for the view that it is the increase in intracellular free calcium that provides the more direct stimulus for the enhanced production of epitectin.


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J. Chambers and A Harris
Expression of the cystic fibrosis gene and the major pancreatic mucin gene, MUC1, in human ductal epithelial cells
J. Cell Sci., January 6, 1993; 105(2): 417 - 422.
[Abstract] [PDF]


© The Company of Biologists Ltd 1987