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Journal of Cell Science, Vol 87, Issue 3 383-388, Copyright © 1987 by Company of Biologists

JOURNAL ARTICLES

The suppression of malignancy by terminal differentiation: evidence from hybrids between tumour cells and keratinocytes

H Harris and ME Bramwell
Sir William Dunn School of Pathology, Oxford, UK.

When malignant human cells are crossed with diploid human keratinocytes, malignancy, as defined by progressive growth in vivo, is suppressed so long as the hybrid cells continue to produce involucrin, a protein that characterizes terminal differentiation in the keratinocyte. When, on continued cultivation in vitro, the cells lose the ability to produce involucrin, they reacquire the ability to grow progressively in the animal.


This article has been cited by other articles:


Home page
 Mol Cancer ResHome page
A. Harris, H. Harris, and M. A. Hollingsworth
Complete Suppression of Tumor Formation by High Levels of Basement Membrane Collagen
Mol. Cancer Res., December 1, 2007; 5(12): 1241 - 1245.
[Abstract] [Full Text] [PDF]

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 J. Cell Sci.Home page
H Harris, J Rawlins, and J Sharps
A different approach to tumour suppression. The Alexandra Kefalides Memorial Lecture
J. Cell Sci., January 9, 1996; 109(9): 2189 - 2197.
[Abstract] [PDF]


© The Company of Biologists Ltd 1987