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Journal of Cell Science, Vol 91, 361-366, Copyright © 1988 by Company of Biologists

Submitted on June 7, 1988
Accepted on July 27, 1988

Inhibition of stenotele commitment by an endogenous factor in Hydra

TOSHITAKA FUJISAWA 1

1 Department of Developmental Genetics, National Institute of Genetics Yata 1111, Mishima, Shizuoka 411, Japan

The precise timing of the inhibition of stenotele differentiation by an endogenous factor in Hydra was localized in the terminal cell cycle of the precursor cells. Animals were treated with crude extract of Hydra and the inhibition kinetics of stenotele differentiation were determined. Comparison of these results with the differentiation kinetics of stenoteles determined by using [3H]thymidine labelling indicated that an endogenous factor inhibited precursor cells from entering the stenotele pathway near the S/G2 boundary of the terminal cell cycle. Since stenotele commitment occurs during this time, these results suggest that an endogenous factor specifically blocks stenotele commitment. Precursor cells blocked by the factor appeared to choose other pathways.

Key words: Hydra, stenotele commitment, stenotele inhibitor

Submitted on June 7, 1988
Accepted on July 27, 1988




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