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Journal of Cell Science, Vol 98, Issue 4 497-506, Copyright © 1991 by Company of Biologists

JOURNAL ARTICLES

Factors influencing perpendicular elongation of embryonic frog muscle cells in a small applied electric field

CD McCaig and PJ Dover
School of Biomedical Sciences, Marischal College, University of Aberdeen, UK.

The mechanism controlling the perpendicular elongation of embryonic muscle cells exposed to a small applied electric field has been studied using a pharmacological approach. Inhibition of the inositol phosphate second messenger system, of calcium entry and of microfilament polymerisation all prevented perpendicular elongation. A model involving strengthened adhesion asymmetrically along the cathodal-facing side of round myoblasts and incorporating the above requirements is proposed to explain electric field-induced perpendicular differentiation. Some asymmetry of organelles is described also, with ribosomes, yolk granules and actin filaments all predominantly found on the anodal side of myoblasts.


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© The Company of Biologists Ltd 1991