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Journal of Cell Science, Vol 99, Issue 2 201-206, Copyright © 1991 by Company of Biologists
JOURNAL ARTICLES |
AP Wolffe
Laboratory of Molecular Biology, NIDDK, NIH, Bethesda, MD 20892.
DNA replication has a key role in many developmental processes. Recent progress in understanding events at the replication fork suggests mechanisms for both establishing and maintaining programs of eukaryotic gene activity. In this review, I discuss the consequences of replication fork passage for preexisting chromatin structures and describe how the mechanism of nucleosome assembly at the replication fork may facilitate the formation of either transcriptionally active or repressed chromatin.
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