spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Nugent, J. H.
Right arrow Articles by Hyams, J. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nugent, J. H.
Right arrow Articles by Hyams, J. S.

Journal of Cell Science, Vol 99, Issue 3 669-674, Copyright © 1991 by Company of Biologists

JOURNAL ARTICLES

Conserved structural motifs in cyclins identified by sequence analysis

JH Nugent, CE Alfa, T Young and JS Hyams
Department of Biology, University College London, UK.

Cyclins, as regulatory subunits of the ubiquitous p34cdc2 protein kinase, act as key controlling elements of the eukaryotic cell cycle. We have examined published sequences of A- and B-type cyclins for both amino acid and secondary structure homologies. In particular, we sought regions of homology outside the recognised area of sequence conservation known as the "cyclin box', as well as conserved features predicted to lie at the protein surface. Our analysis demonstrates the existence of a number of islands of homology outside the cyclin box, and indicates candidate residues for phosphorylation. One of these, a motif containing the amino acids SPXXXE/D is also present in fission yeast p13suc1, another protein known to interact with p34cdc2. This motif may define a possible p34cdc2 binding or phosphorylation site. A database search revealed that the CDC25 and SCD25 genes of the budding yeast Saccharomyces cerevisiae also contain some of the newly identified motifs, perhaps indicating a common regulatory or degradation pathway.


This article has been cited by other articles:


Home page
 Mol. Biol. CellHome page
A. M. Bentley, G. Normand, J. Hoyt, and R. W. King
Distinct Sequence Elements of Cyclin B1 Promote Localization to Chromatin, Centrosomes, and Kinetochores during Mitosis
Mol. Biol. Cell, December 1, 2007; 18(12): 4847 - 4858.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
M. Menges, G. Pavesi, P. Morandini, L. Bogre, and J. A.H. Murray
Genomic Organization and Evolutionary Conservation of Plant D-Type Cyclins
Plant Physiology, December 1, 2007; 145(4): 1558 - 1576.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
G. Wang, H. Kong, Y. Sun, X. Zhang, W. Zhang, N. Altman, C. W. dePamphilis, and H. Ma
Genome-Wide Analysis of the Cyclin Family in Arabidopsis and Comparative Phylogenetic Analysis of Plant Cyclin-Like Proteins
Plant Physiology, June 1, 2004; 135(2): 1084 - 1099.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
L. Martinez-Gac, M. Marques, Z. Garcia, M. R. Campanero, and A. C. Carrera
Control of Cyclin G2 mRNA Expression by Forkhead Transcription Factors: Novel Mechanism for Cell Cycle Control by Phosphoinositide 3-Kinase and Forkhead
Mol. Cell. Biol., March 1, 2004; 24(5): 2181 - 2189.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
L. A. LaPierre, J. W. Casey, and D. L. Holzschu
Walleye Retroviruses Associated with Skin Tumors and Hyperplasias Encode Cyclin D Homologs
J. Virol., November 1, 1998; 72(11): 8765 - 8771.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Brandeis, I. Rosewell, M. Carrington, T. Crompton, M. A. Jacobs, J. Kirk, J. Gannon, and T. Hunt
Cyclin B2-null mice develop normally and are fertile whereas cyclin B1-null mice die in utero
PNAS, April 14, 1998; 95(8): 4344 - 4349.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. C. Horne, K. L. Donaldson, G. L. Goolsby, D. Tran, M. Mulheisen, J. W. Hell, and A. F. Wahl
Cyclin G2 Is Up-regulated during Growth Inhibition and B Cell Antigen Receptor-mediated Cell Cycle Arrest
J. Biol. Chem., May 9, 1997; 272(19): 12650 - 12661.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. C. Horne, G. L. Goolsby, K. L. Donaldson, D. Tran, M. Neubauer, and A. F. Wahl
Cyclin G1 and Cyclin G2 Comprise a New Family of Cyclins with Contrasting Tissue-specific and Cell Cycle-regulated Expression
J. Biol. Chem., March 15, 1996; 271(11): 6050 - 6061.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C Sweeney, M Murphy, M Kubelka, S. Ravnik, C. Hawkins, D. Wolgemuth, and M Carrington
A distinct cyclin A is expressed in germ cells in the mouse
Development, January 1, 1996; 122(1): 53 - 64.
[Abstract] [PDF]

Home page
 J. Biol. Chem.Home page
T. Kaplon and M. Jacquet
The Cellular Content of Cdc25p, the Ras Exchange Factor in Saccharomyces cerevisiae, Is Regulated by Destabilization Through a Cyclin Destruction Box
J. Biol. Chem., September 1, 1995; 270(35): 20742 - 20747.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
G Maridor, P Gallant, R Golsteyn, and E. Nigg
Nuclear localization of vertebrate cyclin A correlates with its ability to form complexes with cdk catalytic subunits
J. Cell Sci., January 10, 1993; 106(2): 535 - 544.
[Abstract] [PDF]

Home page
 J. Biol. Chem.Home page
X. Wang, Y.-P. Ching, W.-H. Lam, Z. Qi, M. Zhang, and J. H. Wang
Identification of a Common Protein Association Region in the Neuronal Cdk5 Activator
J. Biol. Chem., October 6, 2000; 275(41): 31763 - 31769.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 1991