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JCS ePress online publication date 27 Feb 2007
doi: 10.1242/jcs.002212

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Research Article

The ADMA/DDAH pathway is a critical regulator of endothelial cell motility


Beata Wojciak-Stothard*, Belen Torondel, Lillian Yen Fen Tsang, Ingrid Fleming, Beate Fisslthaler, James M. Leiper, and Patrick Vallance
* Author for correspondence (e-mail: B.Wojciak-Stothard{at}ucl.ac.uk)

Asymmetric dimethylarginine (ADMA) is an inhibitor of nitric oxide production associated with abnormal blood vessel growth and repair, however, the mechanism of action of ADMA is not well understood. We studied the role of exogenous and endogenous ADMA in the regulation of cell motility and actin cytoskeleton in porcine pulmonary endothelial cells (PAECs) and pulmonary microvascular endothelial cells (PMECs) from knockout mice that lack one of the enzyme metabolising ADMA, dimethylarginine dimethylaminohydrolase I (DDAHI) as well as endothelial cells overexpressing DDAH in vitro.


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