The fully linked HTML version of this article has now been published.
JCS ePress
online publication date 4 Mar 2003
doi: 10.1242/jcs.00341
Research Article
PARP-3 localizes preferentially to the daughter centriole and interferes with the G1/S cell cycle progression
Angélique Augustin,
Catherine Spenlehauer,
Hélène Dumond,
Josiane Ménissier-de Murcia,
Matthieu Piel,
Anne-Catherine Schmit,
Françoise Apiou,
Jean-Luc Vonesch,
Michael Kock,
Michel Bornens,
and
Gilbert de Murcia*
* Author for correspondence (e-mail: demurcia{at}esbs.u-strasbg.fr)
A novel member of the poly(ADP-ribose) polymerase (PARP) family, hPARP-3, is identified here as a core component of the centrosome. hPARP-3 is preferentially localized to the daughter centriole throughout the cell cycle. The N-terminal domain (54 amino acids) of hPARP-3 is responsible for its centrosomal localization. Full-length hPAPR-3 (540 amino acids, with an apparent mass of 67 kDa) synthesizes ADP-ribose polymers during its automodification. Overexpression of hPARP-3 or its N-terminal domain does not influence centrosomal duplication or amplification but interferes with the G1/S cell cycle progression. PARP-1 also resides for part of the cell cycle in the centrosome and interacts with hPARP-3. The presence of both PARP-1 and PARP-3 at the centrosome may link the DNA damage surveillance network to the mitotic fidelity checkpoint.
This article has been cited by other articles:
|
|
|
|
 
H. Sudo and Y. Maru
LAPSER1/LZTS2: a pluripotent tumor suppressor linked to the inhibition of katanin-mediated microtubule severing
Hum. Mol. Genet.,
August 15, 2008;
17(16):
2524 - 2540.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. O. Hassa, S. S. Haenni, M. Elser, and M. O. Hottiger
Nuclear ADP-Ribosylation Reactions in Mammalian Cells: Where Are We Today and Where Are We Going?
Microbiol. Mol. Biol. Rev.,
September 1, 2006;
70(3):
789 - 829.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. Srsen, N. Gnadt, A. Dammermann, and A. Merdes
Inhibition of centrosome protein assembly leads to p53-dependent exit from the cell cycle
J. Cell Biol.,
August 28, 2006;
174(5):
625 - 630.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H.-Y. E. Chou, H. T. Chou, and S.-C. Lee
CDK-dependent Activation of Poly(ADP-ribose) Polymerase Member 10 (PARP10)
J. Biol. Chem.,
June 2, 2006;
281(22):
15201 - 15207.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Zou, J. Li, Y. Bai, W. T. Gunning, D. E. Wazer, V. Band, and Q. Gao
Centrobin: a novel daughter centriole-associated protein that is required for centriole duplication
J. Cell Biol.,
November 7, 2005;
171(3):
437 - 445.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. C. T. Aguiar, K. Takeyama, C. He, K. Kreinbrink, and M. A. Shipp
B-aggressive Lymphoma Family Proteins Have Unique Domains That Modulate Transcription and Exhibit Poly(ADP-ribose) Polymerase Activity
J. Biol. Chem.,
October 7, 2005;
280(40):
33756 - 33765.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Y. Kim, T. Zhang, and W. L. Kraus
Poly(ADP-ribosyl)ation by PARP-1: `PAR-laying' NAD+ into a nuclear signal
Genes & Dev.,
September 1, 2005;
19(17):
1951 - 1967.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Okano, L. Lan, A. E. Tomkinson, and A. Yasui
Translocation of XRCC1 and DNA ligase III{alpha} from centrosomes to chromosomes in response to DNA damage in mitotic human cells
Nucleic Acids Res.,
January 14, 2005;
33(1):
422 - 429.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Manandhar, H. Schatten, and P. Sutovsky
Centrosome Reduction During Gametogenesis and Its Significance
Biol Reprod,
January 1, 2005;
72(1):
2 - 13.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Lahav, M.-L. Suva, D. Rimoldi, P. H. Patterson, and I. Stamenkovic
Endothelin Receptor B Inhibition Triggers Apoptosis and Enhances Angiogenesis in Melanomas
Cancer Res.,
December 15, 2004;
64(24):
8945 - 8953.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Beneke and A. Burkle
Poly(ADP-Ribosyl)ation, PARP, and Aging
Sci. Aging Knowl. Environ.,
December 8, 2004;
2004(49):
re9 - re9.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Rouleau, R. A. Aubin, and G. G. Poirier
Poly(ADP-ribosyl)ated chromatin domains: access granted
J. Cell Sci.,
February 22, 2004;
117(6):
815 - 825.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Dantzer, M.-J. Giraud-Panis, I. Jaco, J.-C. Ame, I. Schultz, M. Blasco, C.-E. Koering, E. Gilson, J. Menissier-de Murcia, G. de Murcia, et al.
Functional Interaction between Poly(ADP-Ribose) Polymerase 2 (PARP-2) and TRF2: PARP Activity Negatively Regulates TRF2
Mol. Cell. Biol.,
February 15, 2004;
24(4):
1595 - 1607.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. W. Oliver, J.-C. Ame, S. M. Roe, V. Good, G. de Murcia, and L. H. Pearl
Crystal structure of the catalytic fragment of murine poly(ADP-ribose) polymerase-2
Nucleic Acids Res.,
January 22, 2004;
32(2):
456 - 464.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Hanai, M. Kanai, S. Ohashi, K. Okamoto, M. Yamada, H. Takahashi, and M. Miwa
Loss of poly(ADP-ribose) glycohydrolase causes progressive neurodegeneration in Drosophila melanogaster
PNAS,
January 6, 2004;
101(1):
82 - 86.
[Abstract]
[Full Text]
[PDF]
|
|
|
© The Company of Biologists Ltd 2003
