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JCS ePress online publication date 23 Apr 2003
doi: 10.1242/jcs.00526

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Research Article

Rapid transport of neural intermediate filament protein


Brian T. Helfand, Patty Loomis, Miri Yoon, and Robert D. Goldman*
* Author for correspondence (e-mail: r-goldman{at}northwestern.edu)

Peripherin is a neural intermediate filament protein that is expressed in peripheral and enteric neurons, as well as in PC12 cells. A determination of the motile properties of peripherin has been undertaken in PC12 cells during different stages of neurite outgrowth. The results reveal that non-filamentous, non-membrane bound peripherin particles and short peripherin intermediate filaments, termed 'squiggles', are transported at high speed throughout PC12 cell bodies, neurites and growth cones. These movements are bi-directional, and the majority require microtubules along with their associated molecular motors, conventional kinesin and cytoplasmic dynein. Our data demonstrate that peripherin particles and squiggles can move as components of a rapid transport system capable of delivering cytoskeletal subunits to the most distal regions of neurites over relatively short time periods.
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