spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search    

The fully linked HTML version of this article has now been published.
JCS ePress online publication date 2 Dec 2003
doi: 10.1242/jcs.00831

This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
jcs.00831v1
117/2/359    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fieber, C.
Right arrow Articles by Sleeman, J. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fieber, C.
Right arrow Articles by Sleeman, J. P.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Research Article

Hyaluronan-oligosaccharide-induced transcription of metalloproteases


Christina Fieber, Petra Baumann, Rüdiger Vallon, Christian Termeer, Jan C. Simon, Martin Hofmann, Peter Angel, Peter Herrlich, and Jonathan P. Sleeman*
* Author for correspondence (e-mail: sleeman{at}itg.fzk.de)

Activated dendritic epidermal Langerhans cells and metastatic tumour cells share many properties. Both cell types can invade the surrounding tissue, enter the lymphatic system and travel to regional lymph nodes. We have recently shown that fragments of the extracellular matrix component hyaluronan, which are typically produced at sites of inflammation, can activate dendritic cells. Upon activation, dendritic cells upregulate expression of matrix metalloproteases (MMPs). These observations prompted us to investigate whether exposure to hyaluronan fragments also induces MMP expression in tumour cells. Here, we report that MMP-9, MMP-13 and urokinase plasminogen activator are upregulated in murine 3LL tumour cells after exposure to mixed-size hyaluronan. Similarly upregulated MMP-9 and MMP-13 expression was observed in primary fibroblasts. By using size-fractionated hyaluronan preparations, we show that the enhanced expression of MMP-9 and MMP-13 is only induced by small hyaluronan (HA) fragments. Although our data suggest that HA-fragment-induced MMP-9 and MMP-13 expression is receptor mediated, they rule out an involvement of the hyaluronan receptors CD44, RHAMM/IHAP and TLR-4. Finally, we show that HA fragment-induced MMP-9 transcription is mediated via NF-{kappa}B. Our results suggest that the metastasis-associated HA degradation in tumours might promote invasion by inducing MMP expression.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 DevelopmentHome page
M. Shimada, Y. Yanai, T. Okazaki, N. Noma, I. Kawashima, T. Mori, and J. S. Richards
Hyaluronan fragments generated by sperm-secreted hyaluronidase stimulate cytokine/chemokine production via the TLR2 and TLR4 pathway in cumulus cells of ovulated COCs, which may enhance fertilization
Development, June 1, 2008; 135(11): 2001 - 2011.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Kaneiwa, S. Yamada, S. Mizumoto, A. M. Montano, S. Mitani, and K. Sugahara
Identification of a Novel Chondroitin Hydrolase in Caenorhabditis elegans
J. Biol. Chem., May 30, 2008; 283(22): 14971 - 14979.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. Harada and M. Takahashi
CD44-dependent Intracellular and Extracellular Catabolism of Hyaluronic Acid by Hyaluronidase-1 and -2
J. Biol. Chem., February 23, 2007; 282(8): 5597 - 5607.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
S. Boodoo, E. W. Spannhake, J. D. Powell, and M. R. Horton
Differential regulation of hyaluronan-induced IL-8 and IP-10 in airway epithelial cells
Am J Physiol Lung Cell Mol Physiol, September 1, 2006; 291(3): L479 - L486.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. A. Scheibner, M. A. Lutz, S. Boodoo, M. J. Fenton, J. D. Powell, and M. R. Horton
Hyaluronan Fragments Act as an Endogenous Danger Signal by Engaging TLR2
J. Immunol., July 15, 2006; 177(2): 1272 - 1281.
[Abstract] [Full Text] [PDF]

Home page
 Rheumatology (Oxford)Home page
T. Hiramitsu, T. Yasuda, H. Ito, M. Shimizu, S. M. Julovi, T. Kakinuma, M. Akiyoshi, M. Yoshida, and T. Nakamura
Intercellular adhesion molecule-1 mediates the inhibitory effects of hyaluronan on interleukin-1{beta}-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts via down-regulation of NF-{kappa}B and p38
Rheumatology, July 1, 2006; 45(7): 824 - 832.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Ohno, H.-J. Im, C. B. Knudson, and W. Knudson
Hyaluronan Oligosaccharides Induce Matrix Metalloproteinase 13 via Transcriptional Activation of NF{kappa}B and p38 MAP Kinase in Articular Chondrocytes
J. Biol. Chem., June 30, 2006; 281(26): 17952 - 17960.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
W. Selbi, A. J. Day, M. S. Rugg, C. Fulop, C. A. de la Motte, T. Bowen, V. C. Hascall, and A. O. Phillips
Overexpression of Hyaluronan Synthase 2 Alters Hyaluronan Distribution and Function in Proximal Tubular Epithelial Cells
J. Am. Soc. Nephrol., June 1, 2006; 17(6): 1553 - 1567.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. N. Sugahara, T. Hirata, H. Hayasaka, R. Stern, T. Murai, and M. Miyasaka
Tumor Cells Enhance Their Own CD44 Cleavage and Motility by Generating Hyaluronan Fragments
J. Biol. Chem., March 3, 2006; 281(9): 5861 - 5868.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
A. E. Ducale, S. I. Ward, T. Dechert, and D. R. Yager
Regulation of hyaluronan synthase-2 expression in human intestinal mesenchymal cells: mechanisms of interleukin-1{beta}-mediated induction
Am J Physiol Gastrointest Liver Physiol, September 1, 2005; 289(3): G462 - G470.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. Liu-Bryan, K. Pritzker, G. S. Firestein, and R. Terkeltaub
TLR2 Signaling in Chondrocytes Drives Calcium Pyrophosphate Dihydrate and Monosodium Urate Crystal-Induced Nitric Oxide Generation
J. Immunol., April 15, 2005; 174(8): 5016 - 5023.
[Abstract] [Full Text] [PDF]

Home page
 GlycobiologyHome page
C. D. Blundell, P. L. DeAngelis, A. J. Day, and A. Almond
Use of 15N-NMR to resolve molecular details in isotopically-enriched carbohydrates: sequence-specific observations in hyaluronan oligomers up to decasaccharides
Glycobiology, November 1, 2004; 14(11): 999 - 1009.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
W. Jing and P. L. DeAngelis
Synchronized Chemoenzymatic Synthesis of Monodisperse Hyaluronan Polymers
J. Biol. Chem., October 1, 2004; 279(40): 42345 - 42349.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2003