spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search    

The fully linked HTML version of this article has now been published.
JCS ePress online publication date 2 Dec 2003
doi: 10.1242/jcs.00844

This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
jcs.00844v1
117/2/199    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pitt, C. W.
Right arrow Articles by Doonan, J. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pitt, C. W.
Right arrow Articles by Doonan, J. H.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Research Article

The pot1+ homologue in Aspergillus nidulans is required for ordering mitotic events


Christopher W. Pitt, Eric Moreau, Patricia A. Lunness, and John H. Doonan*
* Author for correspondence (e-mail: john.doonan{at}bbsrc.ac.uk)

Orderly progression through mitosis is essential to reduce segregation errors in the cell's genetic material. We have used a cytological screen to identify a mutant that progresses through mitosis aberrantly and have cloned the complementing gene, nimU, which encodes a protein related to Pot1 and other telomere end-binding proteins. We show that loss of nimU function leads to premature mitotic spindle elongation, premature mitotic exit, errors in chromosome segregation, and failure to delay mitotic exit under conditions that normally evoke the mitotic spindle checkpoint response. Whereas premature mitotic exit is dependent upon anaphase promoting complex function, premature spindle elongation is not. We conclude that nimU is constitutively required for orderly mitotic progression under normal growth conditions and also required for the conditional mitotic spindle checkpoint response.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Plant CellHome page
C. Pignocchi, G. E. Minns, N. Nesi, R. Koumproglou, G. Kitsios, C. Benning, C. W. Lloyd, J. H. Doonan, and M. J Hills
ENDOSPERM DEFECTIVE1 Is a Novel Microtubule-Associated Protein Essential for Seed Development in Arabidopsis
PLANT CELL, January 1, 2009; 21(1): 90 - 105.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
P. Rossignol, S. Collier, M. Bush, P. Shaw, and J. H. Doonan
Arabidopsis POT1A interacts with TERT-V(I8), an N-terminal splicing variant of telomerase
J. Cell Sci., October 15, 2007; 120(20): 3678 - 3687.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
E. V. Shakirov, Y. V. Surovtseva, N. Osbun, and D. E. Shippen
The Arabidopsis Pot1 and Pot2 Proteins Function in Telomere Length Homeostasis and Chromosome End Protection
Mol. Cell. Biol., September 1, 2005; 25(17): 7725 - 7733.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
J. T. Bunch, N. S. Bae, J. Leonardi, and P. Baumann
Distinct Requirements for Pot1 in Limiting Telomere Length and Maintaining Chromosome Stability
Mol. Cell. Biol., July 1, 2005; 25(13): 5567 - 5578.
[Abstract] [Full Text] [PDF]

Home page
 Eukaryot CellHome page
J. R. Davies, A. H. Osmani, C. P. C. De Souza, C. Bachewich, and S. A. Osmani
Potential Link between the NIMA Mitotic Kinase and Nuclear Membrane Fission during Mitotic Exit in Aspergillus nidulans
Eukaryot. Cell, December 1, 2004; 3(6): 1433 - 1444.
[Abstract] [Full Text] [PDF]

Home page
 Eukaryot CellHome page
A. Sadanandom, K. Findlay, J. H. Doonan, P. Schulze-Lefert, and K. Shirasu
CHPA, a Cysteine- and Histidine-Rich-Domain-Containing Protein, Contributes to Maintenance of the Diploid State in Aspergillus nidulans
Eukaryot. Cell, August 1, 2004; 3(4): 984 - 991.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2003