spacer gif spacer gif spacer gif spacer gif Propose a workshop for 2011 spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search    

The fully linked HTML version of this article has now been published.
JCS ePress online publication date 16 Nov 2004
doi: 10.1242/jcs.01537

This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
jcs.01537v1
117/25/6153    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Grigoryev, S. A.
Right arrow Articles by Woodcock, C. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Grigoryev, S. A.
Right arrow Articles by Woodcock, C. L.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Research Article

Dynamic relocation of epigenetic chromatin markers reveals an active role of constitutive heterochromatin in the transition from proliferation to quiescence


Sergei A. Grigoryev, Tatiana Nikitina, John R. Pehrson, Prim B. Singh, and Christopher L. Woodcock*
* Author for correspondence (e-mail: chris{at}bio.umass.edu)

Quiescent lymphocytes have small nuclei, filled with masses of facultative heterochromatin. Upon receiving mitogenic signals, these cells undergo nuclear enlargement, chromatin decondensation, the reactivation of cell proliferation, and changes in the intranuclear positioning of key genes. We examined the levels and intranuclear localization of major histone modifications and non-histone heterochromatin proteins in quiescent and reactivated mouse spleen lymphocytes. Dramatic and selective changes in localization of two heterochromatin-associated proteins, the histone variant macroH2A and HP1{alpha} occurred during lymphocyte reactivation. Reciprocal changes in the locations of these two proteins were observed in activated lymphocytes and cultured mouse fibroblasts induced into quiescence. We also describe a new apocentric nuclear compartment with a unique set of histone modifications that occurs as a zone of chromatin surrounding centromeric heterochromatin in differentiated lymphocytes. It is within this zone that the most significant changes occur in the transition from proliferation to quiescence. Our results suggest that constitutive centromeric heterochromatin plays an active role in cell differentiation and reactivation.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Mol. Cell. Biol.Home page
L. N. Changolkar, G. Singh, and J. R. Pehrson
macroH2A1-Dependent Silencing of Endogenous Murine Leukemia Viruses
Mol. Cell. Biol., March 15, 2008; 28(6): 2059 - 2065.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Q. Jin, W. Ding, and K. M. Mulder
Requirement for the Dynein Light Chain km23-1 in a Smad2-dependent Transforming Growth Factor-beta Signaling Pathway
J. Biol. Chem., June 29, 2007; 282(26): 19122 - 19132.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
L. N. Changolkar, C. Costanzi, N. A. Leu, D. Chen, K. J. McLaughlin, and J. R. Pehrson
Developmental Changes in Histone macroH2A1-Mediated Gene Regulation
Mol. Cell. Biol., April 1, 2007; 27(7): 2758 - 2764.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
N. Naetar, S. Hutter, D. Dorner, T. Dechat, B. Korbei, J. Gotzmann, H. Beug, and R. Foisner
LAP2{alpha}-binding protein LINT-25 is a novel chromatin-associated protein involved in cell cycle exit
J. Cell Sci., March 1, 2007; 120(5): 737 - 747.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
K. Ouararhni, R. Hadj-Slimane, S. Ait-Si-Ali, P. Robin, F. Mietton, A. Harel-Bellan, S. Dimitrov, and A. Hamiche
The histone variant mH2A1.1 interferes with transcription by down-regulating PARP-1 enzymatic activity
Genes & Dev., December 1, 2006; 20(23): 3324 - 3336.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
I. K. Greaves, D. Rangasamy, M. Devoy, J. A. Marshall Graves, and D. J. Tremethick
The X and Y Chromosomes Assemble into H2A.Z, Containing Facultative Heterochromatin, following Meiosis.
Mol. Cell. Biol., July 1, 2006; 26(14): 5394 - 5405.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
L. N. Changolkar and J. R. Pehrson
macroH2A1 Histone Variants Are Depleted on Active Genes but Concentrated on the Inactive X Chromosome
Mol. Cell. Biol., June 15, 2006; 26(12): 4410 - 4420.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. I. Young, E. P. Hong, J. C. Castle, J. Crespo-Barreto, A. B. Bowman, M. F. Rose, D. Kang, R. Richman, J. M. Johnson, S. Berget, et al.
Inaugural Article: Regulation of RNA splicing by the methylation-dependent transcriptional repressor methyl-CpG binding protein 2
PNAS, December 6, 2005; 102(49): 17551 - 17558.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
S. Chakravarthy, S. K. Y. Gundimella, C. Caron, P.-Y. Perche, J. R. Pehrson, S. Khochbin, and K. Luger
Structural Characterization of the Histone Variant macroH2A
Mol. Cell. Biol., September 1, 2005; 25(17): 7616 - 7624.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2004