spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search    

The fully linked HTML version of this article has now been published.
JCS ePress online publication date 11 Apr 2006
doi: 10.1242/jcs.02902

This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
jcs.02902v1
119/9/1843    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Walter, D.
Right arrow Articles by Fahrenkrog, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Walter, D.
Right arrow Articles by Fahrenkrog, B.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Research Article

The inhibitor-of-apoptosis protein Bir1p protects against apoptosis in S. cerevisiae and is a substrate for the yeast homologue of Omi/HtrA2


David Walter, Silke Wissing, Frank Madeo, and Birthe Fahrenkrog*
* Author for correspondence (e-mail: birthe.fahrenkrog{at}unibas.ch)

Inhibitor-of-apoptosis proteins (IAPs) play a crucial role in the regulation of metazoan apoptosis. IAPs are typically characterized by the presence of one to three baculovirus IAP repeat (BIR) domains that are essential for their anti-apoptotic activity. Bir1p is the sole BIR-protein in yeast and has been shown to participate in chromosome segregation events. Here, we show that Bir1p is a substrate for Nma111p, which is the homologue of the human pro-apoptotic serine protease Omi/HtrA2 and which is known to mediate apoptosis in yeast. Bir1p is a cytoplasmic and nuclear protein, and yeast cells lacking bir1 are more sensitive to apoptosis induced by oxidative stress. Consistently, overexpression of Bir1p reduces apoptosis-like cell death, whereas this protective effect can be antagonized in vivo by simultaneous overexpression of Nma111p. Moreover, chronologically aged cells that constitutively overexpress Bir1p show a delayed onset of cell death. Therefore, Bir1p, like its closest metazoan homologues deterin and survivin, has dual functions: it participates in chromosome segregation events and cytokinesis and exhibits anti-apoptotic activity.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 J. Cell Sci.Home page
K. D. Belanger, D. Walter, T. A. Henderson, A. L. Yelton, T. G. O'Brien, K. G. Belanger, S. J. Geier, and B. Fahrenkrog
Nuclear localisation is crucial for the proapoptotic activity of the HtrA-like serine protease Nma111p
J. Cell Sci., November 1, 2009; 122(21): 3931 - 3941.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
D. M. Thompson and R. Parker
The RNase Rny1p cleaves tRNAs and promotes cell death during oxidative stress in Saccharomyces cerevisiae
J. Cell Biol., April 6, 2009; 185(1): 43 - 50.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
N. Padmanabhan, L. Fichtner, A. Dickmanns, R. Ficner, J. B. Schulz, and G. H. Braus
The Yeast HtrA Orthologue Ynm3 Is a Protease with Chaperone Activity that Aids Survival Under Heat Stress
Mol. Biol. Cell, January 1, 2009; 20(1): 68 - 77.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
M. T. Andres, M. Viejo-Diaz, and J. F. Fierro
Human Lactoferrin Induces Apoptosis-Like Cell Death in Candida albicans: Critical Role of K+-Channel-Mediated K+ Efflux
Antimicrob. Agents Chemother., November 1, 2008; 52(11): 4081 - 4088.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
Z. Yue, A. Carvalho, Z. Xu, X. Yuan, S. Cardinale, S. Ribeiro, F. Lai, H. Ogawa, E. Gudmundsdottir, R. Gassmann, et al.
Deconstructing Survivin: comprehensive genetic analysis of Survivin function by conditional knockout in a vertebrate cell line
J. Cell Biol., October 20, 2008; 183(2): 279 - 296.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
R. Guerin, G. Arseneault, S. Dumont, and L. A. Rokeach
Calnexin Is Involved in Apoptosis Induced by Endoplasmic Reticulum Stress in the Fission Yeast
Mol. Biol. Cell, October 1, 2008; 19(10): 4404 - 4420.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
C. P. Low, G. Shui, L. P. Liew, S. Buttner, F. Madeo, I. W. Dawes, M. R. Wenk, and H. Yang
Caspase-dependent and -independent lipotoxic cell-death pathways in fission yeast
J. Cell Sci., August 15, 2008; 121(16): 2671 - 2684.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. Hauptmann and L. Lehle
Kex1 Protease Is Involved in Yeast Cell Death Induced by Defective N-Glycosylation, Acetic Acid, and Chronological Aging
J. Biol. Chem., July 4, 2008; 283(27): 19151 - 19163.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
S. Mroczek and J. Kufel
Apoptotic signals induce specific degradation of ribosomal RNA in yeast
Nucleic Acids Res., May 1, 2008; 36(9): 2874 - 2888.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. ProteomicsHome page
E. Fernandez-Arenas, V. Cabezon, C. Bermejo, J. Arroyo, C. Nombela, R. Diez-Orejas, and C. Gil
Integrated Proteomics and Genomics Strategies Bring New Insight into Candida albicans Response upon Macrophage Interaction
Mol. Cell. Proteomics, March 1, 2007; 6(3): 460 - 478.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
S. Buttner, T. Eisenberg, E. Herker, D. Carmona-Gutierrez, G. Kroemer, and F. Madeo
Why yeast cells can undergo apoptosis: death in times of peace, love, and war
J. Cell Biol., November 20, 2006; 175(4): 521 - 525.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2006