spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search    

The fully linked HTML version of this article has now been published.
JCS ePress online publication date 27 Jun 2006
doi: 10.1242/jcs.03013

This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
jcs.03013v1
119/14/2975    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Winter, H.
Right arrow Articles by Knipper, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Winter, H.
Right arrow Articles by Knipper, M.

Research Article

Thyroid hormone receptors TR{alpha}1 and TR{beta} differentially regulate gene expression of Kcnq4 and prestin during final differentiation of outer hair cells


Harald Winter, Claudia Braig, Ulrike Zimmermann, Hyun-Soon Geisler, Jürgen-Theodor Fränzer, Thomas Weber, Matthias Ley, Jutta Engel, Martina Knirsch, Karl Bauer, Stephanie Christ, Edward J. Walsh, JoAnn McGee, Iris Köpschall, Karin Rohbock, and Marlies Knipper*
* Author for correspondence (e-mail: marlies.knipper{at}uni-tuebingen.de)

Thyroid hormone (TH or T3) and TH-receptor {beta} (TR{beta}) have been reported to be relevant for cochlear development and hearing function. Mutations in the TR{beta} gene result in deafness associated with resistance to TH syndrome. The effect of TR{alpha}1 on neither hearing function nor cochlear T3 target genes has been described to date. It is also uncertain whether TR{alpha}1 and TR{beta} can act simultaneously on different target genes within a single cell. We focused on two concomitantly expressed outer hair cell genes, the potassium channel Kcnq4 and the motor protein prestin Slc26a5. In outer hair cells, TH enhanced the expression of the prestin gene through TR{beta}. Simultaneously Kcnq4 expression was activated in the same cells by derepression of TR{alpha}1 aporeceptors mediated by an identified TH-response element, which modulates KCNQ4 promoter activity. We show that T3 target genes can differ in their sensitivity to TH receptors having the ligand either bound (holoreceptors) or not bound (aporeceptors) within single cells, and suggest a role for TR{alpha}1 in final cell differentiation.


This article has been cited by other articles:


Home page
 Hum Mol GenetHome page
P. Heidrych, U. Zimmermann, A. Bress, C. M. Pusch, P. Ruth, M. Pfister, M. Knipper, and N. Blin
Rab8b GTPase, a protein transport regulator, is an interacting partner of otoferlin, defective in a human autosomal recessive deafness form
Hum. Mol. Genet., December 1, 2008; 17(23): 3814 - 3821.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
T. Weber, M. K. Corbett, L. M. L. Chow, M. B. Valentine, S. J. Baker, and J. Zuo
Rapid cell-cycle reentry and cell death after acute inactivation of the retinoblastoma gene product in postnatal cochlear hair cells
PNAS, January 15, 2008; 105(2): 781 - 785.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
J. Ashmore
Cochlear Outer Hair Cell Motility
Physiol Rev, January 1, 2008; 88(1): 173 - 210.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
L. Quignodon, S. Vincent, H. Winter, J. Samarut, and F. Flamant
A Point Mutation in the Activation Function 2 Domain of Thyroid Hormone Receptor {alpha}1 Expressed after CRE-Mediated Recombination Partially Recapitulates Hypothyroidism
Mol. Endocrinol., October 1, 2007; 21(10): 2350 - 2360.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
K. R. Johnson, C. C. Marden, P. Ward-Bailey, L. H. Gagnon, R. T. Bronson, and L. R. Donahue
Congenital Hypothyroidism, Dwarfism, and Hearing Impairment Caused by a Missense Mutation in the Mouse Dual Oxidase 2 Gene, Duox2
Mol. Endocrinol., July 1, 2007; 21(7): 1593 - 1602.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
N. Brandt, S. Kuhn, S. Munkner, C. Braig, H. Winter, N. Blin, R. Vonthein, M. Knipper, and J. Engel
Thyroid Hormone Deficiency Affects Postnatal Spiking Activity and Expression of Ca2+ and K+ Channels in Rodent Inner Hair Cells
J. Neurosci., March 21, 2007; 27(12): 3174 - 3186.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2006