|
|
|
|
|
|
|
|
|||||
| Home Help Feedback Subscriptions Archive Search | |||||
The fully linked HTML version of this article has now been published.
Endoplasmic reticulum (ER) and mitochondria are multifunctional cell organelles and their involvement in Ca2+ handling is important in various neural activities. In the respiratory neurons, we observed ER as continuous reticulum in the soma and as isolated vesicles in dendrites. The vesicles moved bidirectionally with intermittent stops and decreased their velocity near exocytotic sites. ER vesicles and mitochondria that resided in these regions changed lumenal Ca2+ and mitochondrial potential in concert with synaptic activity. Ca2+ release from ER or mitochondria evoked exocytosis. ER vesicles and mitochondria bidirectionally exchanged Ca2+, the efficacy of which depended on the distance between organelles. Depolarisation-evoked exocytosis had different kinetics, depending on whether functional ER vesicles and mitochondria were present in perisynaptic regions and able to exchange Ca2+ or only one organelle type was available. Transfer of Ca2+ from ER to mitochondria produced long-lasting elevations of residual Ca2+ that increased the duration of exocytosis. In slice preparations, synaptic currents in inspiratory neurons were suppressed after disengagement of ER vesicles and mitochondria, and the activity was potentiated after stimulation of Ca2+ exchange between the organelles. We propose that communication between perisynaptic ER vesicles and mitochondria can shape intracellular Ca2+ signals and modulate synaptic and integrative neural activities.
This article has been cited by other articles:
JCS ePress
online publication date 14 Nov 2006
doi: 10.1242/jcs.03254
This Article 
Full Text (PDF)
All Versions of this Article:
jcs.03254v1
119/23/4926
most recent
Alert me when this article is cited
Alert me if a correction is posted
Services
Email this article to a friend
Similar articles in this journal
Similar articles in PubMed
Alert me to new issues of the journal
Download to citation manager
Citing Articles
Citing Articles via HighWire
Citing Articles via Google Scholar
Google Scholar
Articles by Mironov, S. L.
Articles by Symonchuk, N.
Search for Related Content
PubMed
PubMed Citation
Articles by Mironov, S. L.
Articles by Symonchuk, N.
Social Bookmarking
What's this?
Research Article
ER vesicles and mitochondria move and communicate at synapses
* Author for correspondence (e-mail: smirono{at}gwdg.de)
CiteULike Complore Connotea Del.icio.us Digg Reddit Technorati Twitter What's this?
Y. S. Kanwar and L. Sun
Shuttling of calcium between endoplasmic reticulum and mitochondria in the renal vasculature
Am J Physiol Renal Physiol,
November 1, 2008;
295(5):
F1301 - F1302.
[Full Text]
[PDF]
S. L. Mironov
Metabotropic glutamate receptors activate dendritic calcium waves and TRPM channels which drive rhythmic respiratory patterns in mice
J. Physiol.,
May 1, 2008;
586(9):
2277 - 2291.
[Abstract]
[Full Text]
[PDF]
A. V. Zhdanov, M. W. Ward, J. H. M. Prehn, and D. B. Papkovsky
Dynamics of Intracellular Oxygen in PC12 Cells upon Stimulation of Neurotransmission
J. Biol. Chem.,
February 29, 2008;
283(9):
5650 - 5661.
[Abstract]
[Full Text]
[PDF]
C. J.R. Loewen, B. P. Young, S. Tavassoli, and T. P. Levine
Inheritance of cortical ER in yeast is required for normal septin organization
J. Cell Biol.,
November 5, 2007;
179(3):
467 - 483.
[Abstract]
[Full Text]
[PDF]
M. W. Ward, H. J. Huber, P. Weisova, H. Dussmann, D. G. Nicholls, and J. H. M. Prehn
Mitochondrial and Plasma Membrane Potential of Cultured Cerebellar Neurons during Glutamate-Induced Necrosis, Apoptosis, and Tolerance
J. Neurosci.,
August 1, 2007;
27(31):
8238 - 8249.
[Abstract]
[Full Text]
[PDF]
© The Company of Biologists Ltd 2006